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Is it possible to design responsive ux in ThingWorx mash ups. It should work fine both in mobile and desktops as an application.
With a single mashup it's hard to reach, but you can set a Mashup for Desktop and a Mashup for Mobile, it's not best solution but it will work.
By the way, If you are doing a mobile App, better to go to a Mobile App development rather than stuck on a raw web interface, which never will satisfy users...
And always it will depend on what you want to reach as "Responsive".