What is the best performing general configuration?
There is no defined answer here as the performance is dependent on many factors, including your system hardware specs.
You may, however, refer to this sizing calculator ThingWorx 7.x Core Deployment Sizing Calculator - PTC.com
and the Sizing Guide http://support.ptc.com/WCMS/files/172249/en/ThingWorx_Core_7.x_Sizing_Guide.pdf
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